Wheeler Mission works with the following organizations to help serve the homeless and those in need in Indianapolis:
- Adult & Child
- American Association of Retired Persons (AARP)
- Central Indiana Council of Aging (CICOA)
- Coalition for Homelessness Intervention and Prevention
- Gennesaret Free Clinic
- Gleaners Food Bank
- Good News Ministries
- Horizon House
- Indiana University Medical School
- Indianapolis Mentropolitan Police Department
- Indianapolis Public Schools
- Indy’s 88.3 Shine.FM